January 17, 20121) I think that probably Shawn, who is described as "a believer", starts the plot deeply motivated by a quasi-religious desire to know the Engineers/Creators. We can bet that a major twist will be her disillusionment. But this is so predictable that I believe Scott has something else, probably bigger, under his hat.
2) I think we see the suits. This can come as a downside for most fans, but I really believe that the Engineers will be much less "alien" than that most people expect. The reason is, in the "Von Daniken" mithology Scott seems to be adopting in this movie, we are very likely created in the Engineer´s image.
3) The derelict in Alien is a) heavily weathered and b) embebbed in Xenomorph goo, that made a nest of it. So it´s only natural. Go see what most shipwrecks seems just now.
4) If xenomorphs really share their host DNA for body plan, we have to acknowledge that with the exception of Alien 3´s xenomorph (breed on the dog) all xenos we have seen are human-based ones. We NEVER saw the Engineer-bred xenomorph (albeit, if the Engineers are similar to us, the resulting xeno must be similar also), and we NEVER saw a "pure" xeno, if this thing exists. What I think we´re gonna see is this, the "pure" xeno. And maybe something else; i´m really curious about what happens in Shaw´s belly.