bigbibsJune 04, 2012My theory is that returning Engineer DNA - in the form of humans - is what wakes the ship and its contents. It's even possible that that was the original plan; when the Engineers "progeny" is able to find the Engineer's point of origin (hence the star map/invitation), then their planet is ready to be re-colonised by the Engineers. The Engineers create a terrible biological weapon, a species whose life cycle they control (what becomes the Xeno), to purge planets of all life that could threaten them (e.g. Us). But it gets out, grows out of their control and destroys them. Does the changing mural in the ampule room not suggest that the Xeno was always meant to be the end result? Or have the walls of the room merely recorded events, as the ship is obviously able to do?
The only reason they're denying this is a prequel is so they can take the story in a new direction and kick-start a new franchise. They want their cake and they want to eat it. Two of the clunkiest, unintentionally laugh-inducing lines (in a pretty clunky, laugh-inducing script) refer to the Engineers running away from something. Ooooh! What could that be?
For me, this film answers the question of the blown out chest on the derelict on LV-426: the Engineers were transporting their weapon, it got out, it killed them all. Maybe it destroyed their civilisation, but ultimately, it was of their own making.